Study of level of malondialdehyde and total antioxidant capacity (TAC) in human lens epithelial cells of diabetic and senile cataract patients

Background: Oxidative stress is a condition where the balance between production and elimination of reactive oxygen species (ROS) disturbed. ROS can cause damage to various biomolecules, including DNA. DNA impair function survival cells, may contribute development cataracts. Several experimental studies have shown that oxidative involved in cataract formation by inducing lens cells.. are created diabetic tissues glucose autoxidation as well non-enzymatic protein glycation. thought play significant role microvascular problems individuals Objectives: To measure levels total antioxidant capacity Malondialdehyde (MDA) nondiabetic senile patients comparison them. Patients methods: Thirty Senile cases 30 aged 50-80 years who were brought ophthalmology ward Acharya Vinoba Bhave Rural Hospital for surgery used TAC assay malondialdehyde determination epithelial cells cataract. Results: was decreased human group. more reduced than group, it not statistically significant. higher MDA Diabetic compared patients. Conclusion: The conclusion present study diabetes ocular complications affecting eye. This because lower their These factors pathogenesis Received: 23 June 2023 Accepted: 09 August Published: 25